Australian researchers have unmasked a molecule behind heart diseases - one the biggest killers in the developed world. The research hinges on a particular molecule, known as a transcription factor, which switches genes on and off. "This is about the oldest known transcription factor, Sp1, which was thought to play a quiet, reclusive role in our blood vessels. (But) our research has found that Sp1 undergoes a sudden chemical reaction that can lead to a heart attack," said the study's co-author Levon Khachigian of the Centre for Vascular Research.

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